The Mediterranean space is affected by a wave of interlocking and multidimensional geopolitical challenges that manifest themselves across critical flashpoints such as the Israel-Palestine question, Syria’s transition, fragmentation in Libya, instability in the Red Sea, and migration flows. The crisis of multilateralism that defines the current configuration of the international system contributes to the exacerbation of these regional trends and further complicates efforts to end conflicts and restore stability. In this context, the revival of international cooperation represents a crucial imperative in the quest for peace, stability and prosperity. The goal of this event is to promote an interactive and informed discussion aimed at understanding how multilateral cooperation can be employed to solve the geopolitical crises that are destabilizing the Mediterranean.